Coal Tar and Cutaneous Carcinogenesis in Industry

Coal tars and coal tar pitches.

Numerous studies, mostly case reports, have found that occupational exposure to coal tars or coal-tar pitches (coal-tar distillates) is associated with skin cancer, including scrotal cancer; workers in these studies have included patent-fuel (coal-briquette) workers, pitch loaders, workers in electrical trades, and optical-lens polishers (IARC 1985, 1987). A 1946 study in the United Kingdom fou...

Cold Applied Coal Tar Paints

Co-carcinogenesis: Human Papillomaviruses, Coal Tar Derivatives, and Squamous Cell Cervical Cancer

Cervical cancer (CC) is the fourth most common cancers among women worldwide. Human papillomaviruses (HPVs) play a major role in the etiology of CC, with several lines of epidemiologic and experimental evidence supporting a role for non-viral (co-carcinogens) and host genetic factors in controlling the risk for progression to neoplasia among HPV-infected individuals. The role of co-carcinogens ...

Primary Lung Tumors in Mice following the Cutaneous Application of Coal Tar

The external application of tar to a number of separated areas on the surface of mice, in such fashion that no single area is irritated sufficiently long to cause lesions of the skin, has resulted in a very high incidence of lung tumors. This incidence ranged from 60.0 per cent in one experiment to 78.3 per cent in another. Control mice from the same stock but from 3 to 6 months older, and for ...

Coal Tar Analysis by Lc/ms

The production of liquids from coal gives rise to complex intermediates which require detailed analysis to understand the processes occurring and to make effective use of the products. Analysis has hitherto been based on structural parameters from NMR methods (1) to give the average characteristics of the sample, supplemented by molecular information from GC and GC/MS. The gas chromatographic a...